WHO Recommends New Treatment Guidelines For Severe COVID-19 Patients

Written by on July 7, 2021

The World Health Organisation has updated its patient care guidelines to include interleukin-6 receptor blockers, a class of medicines that are lifesaving in patients who are severely or critically ill with COVID-19, especially when administered alongside corticosteroids.

The new recommendation was informed by findings from a network meta-analysis initiated by the WHO.

According to the WHO, prospective and living network meta-analyses were the largest on the drugs to date, noting that data from over 10,000 patients enrolled in 27 clinical trials were studied.

The UN agency noted that the interleukin-6 receptor blockers are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020.

“Patients severely or critically ill with COVID-19 often suffer from an overreaction of the immune system, which can be very harmful to the patient’s health.

“Interleukin-6 blocking drugs – tocilizumab and sarilumab – act to suppress this overreaction.

“The prospective and living network meta-analyses showed that in severely or critically ill patients, administering these drugs reduce the odds of death by 13 percent, compared to standard care. This means that there will be 15 fewer deaths per thousand patients and as many as 28 fewer deaths for every thousand critically ill patients. The odds of mechanical ventilation among severe and critical patients are reduced by 28 percent, compared with standard care. This translates to 23 fewer patients out of a thousand needing mechanical ventilation,” WHO said in a statement made available to newsmen.

It added that clinical trial investigators in 28 countries shared data with WHO, including pre-publication data, adding that researchers worldwide compiled and analyzed the data.

The global health body noted that with the support of its critical partners, WHO has been able to issue a rapid and trustworthy recommendation for the use of interleukin-6 receptor blockers in severe and critical COVID-19 patients.

“These drugs offer hope for patients and families who are suffering from the devastating impact of severe and critical COVID-19. But IL-6 receptor blockers remain inaccessible and unaffordable for the majority of the world,” said WHO Director-General Dr. Tedros Adhanom Ghebreyesus.

“The inequitable distribution of vaccines means that people in low- and middle-income countries are most susceptible to severe forms of COVID-19.

“So, the greatest need for these drugs is in countries that currently have the least access. We must urgently change this.

“To increase access and affordability of these life-saving products, WHO calls on manufacturers to reduce prices and make supplies available to low-and middle-income countries, especially where COVID-19 is surging.

WHO also encourages companies to agree to transparent, non-exclusive voluntary licensing agreements using the C-TAP platform and the Medicines Patent Pool, or to waive exclusivity rights.

In addition, WHO has launched an expression of interest for the prequalification of manufacturers of interleukin-6 receptor blockers. Prequalification of innovator and biosimilar products aims to expand the availability of quality-assured products and to increase access through market competition and reduce prices to meet urgent public health needs.


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