Pre-eclampsia risk during pregnancy lowered with high fibre diet

Written by on July 12, 2019

An Australian study has revealed that eating a high-fibre diet during pregnancy could reduce the risk of pre-eclampsia, a serious illness which could lead to allergies and autoimmune illnesses in babies later in life.

Researchers from the University of Sydney’s Charles Perkins Centre, the Barwon Infant Study from Deakin University, Monash University, James Cook University and the Australian National University released the joint study.

Senior author, Prof. Ralph Nanan from UoS said that the link between diet and pre-eclampsia was due to acetate, a compound produced in the gut bacteria of mothers as they processed fibre.

Currently, pre-eclampsia occurs in up to 10 per cent of pregnancies and symptoms include high blood pressure, protein in the urine, and severe swelling in the mother, frequently leading to preterm deliveries.The first revelation of the study was to directly link acetate with mothers, who develop pre-eclampsia.

“We measured acetate levels in (a group of pregnant women) and we found that mothers, who developed pre-eclampsia have significantly lower levels of acetate than mothers who are healthy,” Nanan said.

Then, through experiments on mice, the researchers showed that the development of an important immune organ called the thymus was greatly reduced but could be rescued through the acetate.

“Babies from pre-eclamptic pregnancies have a smaller organ, an immune organ called the thymus which sits behind your breastbone.

“And the thymus is actually a very important immune organ because it produces cells which prevent allergies and autoimmune disease.

“So what this means is that we now have a mechanism to understand why a diet low in fibre, like the Western diet, is associated with more allergies and autoimmune disease later in life,” Nanan explained.

Based on the research, Nanan recommends pregnant women maintain a diet high in plant-based and unprocessed foods, which he said could be better for health.

“Eat real food, not processed food; it should mainly be plant-based.

“A bit of meat and a bit of fish, but mostly plant-based and not too much,” he added.

According to Nanan, Chinese diet which tends to include a lot of vegetables and unprocessed foods is better than the western diet which includes a high amount of preservatives.

The teams responsible for the study hope that further research will confirm the link between fibre and pre-eclampsia and could lead to prevention of the disease as well as reduced instances of allergies and autoimmune disease later in life.



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